Not on the strength of an expected outcome. Nothing about the programme requires disposing of a Canadian business in advance, and doing so removes both an asset and the basis for several alternative routes.
Keep the fallback intact
Selling first feels decisive and usually is not. An operating Canadian company is more than a source of proceeds: it can be the employer abroad in a transfer case, the parent of a future U.S. entity, or evidence of business experience in an investment case.
Disposing of it narrows the field to one route at exactly the moment when keeping options open matters most. There is also a timing problem. Programmes created by executive action can have their procedures adjusted, and an applicant who has already sold, resigned and relocated has no ability to absorb a change.
The better order is to obtain clear official information about the process, take advice on it, keep the business running, and reassess once there is something concrete to react to.